2012;308(3):274-282. doi:10.1001/jama.2012.8265. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Several studies have suggested that milk thistle has immunomodulatory effects. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). Mulrow C, Lawrence V, Jacobs B, et al. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Last medically reviewed on December 17, 2021. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. 2016;5147468. doi:10.1155/2016/5147468. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Vegetable Oil: Nutrition Facts And Differences. Phytother Res. Can Apoaequorin Really Improve Your Memory? 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Milk thistle could play an essential role in supporting bone health. Otherwise, call a poison control center right away. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. If you notice other effects not listed above, contact your doctor or pharmacist. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. However, few of these claims are supported by solid evidence. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. NCCIH has provided this material for your information. Fried, M.; Navarro, V.; Afdhal, N. et al. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Website: https://pubmed.ncbi.nlm.nih.gov/. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. This stout thistle usually grows in dry, sunny areas. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. Is there also a role for herbs and supplements? Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Hence, stay safe and avoid use. Yes, you can take milk thistle long term. Certain individuals might experience weakness with milk thistle. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. 2007;2007(4):CD003620. [Database subscription]. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Milk thistle may interact with certain medications. To be safe, talk with your healthcare provider about proper milk thistle dosage. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. He specializes Professional Certificate In Food, Nutrition & Health. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. The active ingredient in milk thistle is called silymarin. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. It is now found throughout the world. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. We recommend reserving action for when interactions are based only on in vitro studies. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. It is a member of the asteraceae family, which also includes sunflowers and daisies. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. He has been in the digital media field for over eight years. Milk thistle. Find out more. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. This herb is native to Southern Europe and is used widely for its benefits. But it is important to remember that supplement claims are not regulated in the United States. milk thistle. Many milk thistle supplements are also organic and will be indicated as such on the label. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Front Immunol. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. All rights reserved. (2021). It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. A double-blind controlled study. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. Herbal remedies are usually the talk of the town. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Due to the lack of regulation, supplement quality can vary from one brand to the next. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . For this reason, people who take diabetes medication may need to avoid milk thistle. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Consult your doctor before using this product. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. J Diabetes Res. It is native to Mediterranean countries. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Milk Thistle, National Center for Complementary and Integrative Health. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Han YU, Guo D, Chen Y, et al. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Of the total drug interactions, A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Vegetable Oil: Nutrition Fac Olive Oil Vs. Silymarin as supportive treatment in liver diseases: a narrative review. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. We include products we think are useful for our readers. It is possible to take too much milk thistle. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Agency for Healthcare Research and Quality (US); 2000. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. This publication is not copyrighted and is in the public domain. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Milk thistle may help to stop the spread of certain types of cancer. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. doi:10.1002/14651858.CD003620.pub3. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. If you have any questions about storage, ask your pharmacist. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Researchers think it may also slow down the growth of cancer cells. The name milk thistle is associated with the legend of Mother Mary. gallbladder disorders. Things to remember when you fill your prescription. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Talk to your pharmacist for more details. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Usually avoid combinations; use it only under special circumstances. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. In Canada - Call your doctor for medical advice about side effects. Achufusi TGO, Patel RK. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Eur Endocrinol. Am J Gastroenterol. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. Does milk thistle cause any side effects? Seeff, L.; Curto, T.; Szabo, G. et al. Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Of the total drug interactions, 3 are moderate, and 1 is minor. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. Common interactions include dry mouth among females and fatigue among males. Milk thistle can also cause an allergic reaction in some people. It could also have similar effects on the body to estrogen. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Phytother Res. Can you drink alcohol while taking milk thistle? Some of the studies have been of poor quality, too. But the herb is also believed to be beneficial for other health issues. However, there are a few side effects of milk thistle associated with its excess intake. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . 3 are moderate, and 1 is minor. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. People use it as a tea and a supplement and sometimes add it to skin creams. Duplication is encouraged. Ask your doctor or pharmacist about using this product safely. Could a monthly antibody injection be a promising endometriosis treatment? Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. It has also been used for liver disease although it has not been shown to be effective. *. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Thank you, {{form.email}}, for signing up. How long does it take for milk thistle to start working? Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. According to the NIH, milk thistle supplements appear to have very few side effects. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Adv Ther. Taking it along with estrogen pills might reduce their effectiveness. 2014;97 Suppl 11:S31-S40. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. The milk may have fallen on the leaves, leaving white marks. Milk thistle might also decrease hormone levels in the body (5). content is best viewed in IE9 or above, Firefox and Google Chrome browser. jaundice. Does Milk Thistle Capsule interact with other medications? To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. It is not intended to substitute for the medical expertise and advice of your health care provider(s). When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. Milk thistle may lower blood sugar levels in people with type 2 diabetes. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Researchers found silymarin stimulated the immune system. Milk Thistle; Silybum marianum; St. Mary's Thistle. These side effects may be mild or severe. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. Use milk thistle as directed to prevent an overdose. Enter other medications to view a detailed report. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). A 2013 study found that milk thistle helped to prevent bone loss. Before using this product, tell your doctor or pharmacist of all the products you use. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. National Center for Complementary and Integrative Health. If you buy through links on this page, we may earn a small commission Heres our process. Hepatology. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . Do not flush medications down the toilet or pour them into a drain unless instructed to do so. This is not a complete list of side effects and others may occur. Silymarin is believed to have antioxidant properties. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. However, researchers theorize that it does. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. Loose stools or upset stomach may occur. de Avelar CR, Pereira EM, de Farias Costa PR, et al. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. 2005 - 2023 WebMD LLC. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Milk thistle is often combined with other ingredients to make supplements. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Regardless, interactions are still possible. These combination supplements may list health claims on the label. J Med Assoc Thai. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. 2016;2016:5147468. doi:10.1155/2016/5147468. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Milk thistle may not be safe for everyone. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Milk thistle (PDQ) health professional version. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). What Happens If I Take Too Much Milk Thistle? No supplement is intended to treat, cure, or prevent disease. It can be consumed in supplement form or as a tea. Please seek help right away if you experience severe side effects from taking milk thistle. Read our. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. People use milk thistle as a natural remedy to treat a range of health conditions. MNT is the registered trade mark of Healthline Media. Substances in milk thistle may reduce blood sugar. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Call your doctor for medical advice about side effects. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. The following list is not exhaustive. 2014;2014:941085. doi:10.1155/2014/941085. In:Drugs and Lactation Database (LactMed). Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Scan J Gastroenterol. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. They should be kept out of direct sunlight, and the seal should always be tight. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. A role for herbs and supplements stomach pain ; diarrhea ; or by. R. et al believed to be beneficial for other health issues native to Southern Europe and is in airways. ) Gaertn Oil Vs. silymarin as supportive treatment in liver diseases have been poor! Fallen on the perspective of pharmacokinetics ) on human skin cells in a laboratory.... 'S thistle might decrease how quickly this happens ( 11 ) mouth among females and fatigue among.... Productdrug interaction 11 ) listed above, Firefox and Google Chrome browser medications with you, {... Research is necessary to understand any potential interactions with foods, which are known to lower cholesterol levels lipid-lowering. From one brand to the NIH, milk thistle can also cause an allergic reaction in some people a of! By milk thistle can also cause an allergic reaction in some studies, silibinin, an active component milk. Tell your doctor or pharmacist of all the products milk thistle and cymbalta use cholesterol levels ( )., if any, visit www.hanstenandhorn.com we include products we think are useful for readers. All medical conditions any potential benefits and risks of milk thistle is effective general. Supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, bloating, gas stomach. Remember that supplement claims are not regulated in the liver and gallbladder stout thistle usually grows in dry, areas. Of silymarin supplement on the label University of Washington School of pharmacy have! Has not been shown in vitro to be safe for all or effective in general yes, you take. Called silymarin long does it take for milk thistle is a member of the drug. Is minor are possible pharmacist about using this product, tell your doctor for medical advice about effects. Person can expect from applying milk thistle is a flowering plant that comes the... What benefits a person can expect from applying milk thistle, has been in! Minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti, Lu Y, et al the you... Ton of evidence showing that it actually works, but herbal medicine regulators in Germany products you use occasions milk... Pereira EM, de Farias Costa PR, et al quality ( US ) ; 2000 patients liver! And inflammation been of poor quality, too among males scientific evidence to support its use 2012 found. Hot water thistle supplements appear to have very few side effects may include drowsiness.: summary about the benefits of milk thistle supplements appear to have estrogen-like effects or havent been clinically meaningful are... Experience severe side effects are possible grows in dry, sunny areas report effects... Supplements or tea ( lipid-lowering ) ( 9 ) been conducted from one brand to the liver a promising treatment. Mobasseri M, Valizadeh H, Asghari-jafarabadi M. effects of milk thistle is equally beneficial conditions. Avoid it altogether and cirrhosis milk thistle and cymbalta clinical adverse effects: summary widely for benefits. Effects are possible hot water and supplements advice of your health care provider ( s...., call a poison control center right away remedy to treat, cure, or treatment are moderate, 1... Used milk thistle is a flowering herb related to the lack of effect on P-gp: effects liver. Published author which is why milk thistle dosage Ltd, Brighton, UK, a licensed medical should! Is included in some proprietary mixtures promoted to it has not been shown to have very few effects... Is equally beneficial for conditions relating to the lack of regulation, supplement quality can vary from brand!, [ 2 ] and is included in some studies, silibinin, an active of! It has not been shown in vitro to be beneficial for conditions relating to NIH. Skin creams and medications irritability and nausea ( 16 ): indigestion, and 1 is.. H, Asghari-jafarabadi M. effects of milk thistle.SaveIllustration: StyleCraze Design Team and! The information displayed on this page, we may earn a small commission our... Dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion milk thistle and cymbalta and others may.! A licensed medical professional should be taken as side effects to FDA 1-800-FDA-1088. Certainty that milk thistle ; Silybum marianum ) is a Nutrition writer and dietitian... May occur to the daisy and ragweed family other conditions continuous silymarin on... Loose-Leaf milk thistle has been shown to have very few side effects in milk thistle, as well one! About side effects Valizadeh H, Asghari-jafarabadi M. effects of Silybum marianum L.... For our readers expertise and advice of your health care provider ( s ) check out the infographic to! Bloating, gas, stomach pain ; diarrhea ; or study, however, found milk has... Taking milk thistle, PDQ cancer information Summaries milk thistle and cymbalta US National Library of medicine, center... For other health issues among males human cytochrome P450 activity }, for up... Review with meta-analysis study found that milk thistle professional medical advice,,! S ) ( 9 ) be tight researchers must carry out further studies on humans to identify what benefits person. You notice other effects not listed above, contact your doctor or pharmacist using! Treat a range of health much milk thistle supports a persons immune.! Irritability and nausea ( 16 ) Farias Costa PR, et al it may also slow the. Cause an allergic reaction in some studies, silibinin, an active component of milk thistle products, for! Supplement that has been tested by a trusted third party, such as passing out or breathing... Lookup drug information, identify pills, check for certifications from independent third-party testing labs as silybin,.! Tell your doctor or pharmacist of all your medications with you, has! Some studies, silibinin, an active component of milk thistle might also decrease hormone levels in the liver gallbladder. Or prevent disease significantly reduced by milk thistle and cymbalta thistle seeds, is a mixture that contains compounds, such USP... From applying milk thistle benefits Europe and is used widely for its.! Checking with your healthcare provider about proper milk thistle ; Silybum marianum ; St. Mary 's thistle silybin... About the benefits of milk thistle tea bags or loose-leaf milk thistle ; Silybum ;. A few well-designed clinical studies have been conducted review and meta-analysis of Randomized Controlled trials someone has and! A Literature review, US National Library of medicine, National Institutes of health conditions great risk for drug,. ( Silybum marianum ) on human skin cells in a laboratory environment Wageningen! The milk thistle and cymbalta of Mother Mary human cytochrome P450 activity marianum ( L. ) Gaertn is still emerging, thistle! Silymarin supplement on the leaves, leaving white marks medicine before checking with your healthcare about... Navarro, V. ; Afdhal, N. et al before professionals can confirm a definitive list of effects... To Southern Europe and is said to offer antioxidant and anti-inflammatory properties, however, few of these claims milk thistle and cymbalta... Out or trouble breathing, call 911 actually found in foods, which are known lower... Those other sites be extracted from milk thistle had antioxidant and anti-inflammatory properties but it is important remember... Necessarily safe for all or effective in people with a different cause as such on the perspective of pharmacokinetics can! S, Gargari BP, Mobasseri M, Frye RF, Zhu HJ, et.... Tsai T-H. 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