SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. So now I dont know where to turn and its almost time for his monthly treatment again. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. The majority of canines will be fine, but there are enough who will react. It was the amount of ticks Ive been having to remove that lead me to your article! GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. It probably is the safest as it is aimed only at preventing heartworm. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Submit a story, ask a question, or just say hi; Emily would love to hear from you. Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. . At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. Best of luck with your new girl! I found it extremely helpful & educational. My two cats were father and son so probably carried the same gene. Im sincerely grateful!! Thank you for fostering! Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Hi Emily, But of course, do talk to your vet and see what they know. Dash is MDR1 mutant/normal. I just took her off Sentinel Flavor Tabs. Thats what I plan to use in future, when my oldest dog reaches that point. My question is about Capstar. Dogs and cats . Microfilaria and adult heartworm antigen testing. Thank you! Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Thank you for this thorough and thoughtful work, Emily! Whats the best safest flea tick treatment for a collie puppy? As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. So we started her back on Sentinel earlier this year, she really had stomach issues. We have a almost 10 year old tricolor rough collie, named Hollie. Best of luck to you and Sugar! We recently switched our dogs to a new product called Simparica Trio. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; . My dogs are on Sentinel right now and Frontline Gold. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! 1x 10mg tablet for 5.6 to 11 pounds. I read that you you used this combination with success. I would appreciate your comments on Advocate. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. Is this true? Simparica Trio 11.1-22 lbs. MDR1 FAQs. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . Simparica Trio (133) 133 Reviews | Answered Questions. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. This article (authored by two veterinarians) is an excellent resource for more professional information. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! Thank you! Thank you for such a great article! Super useful research. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. No treatment-related clinical signs were observed. Heartgard got a bad rap after too many dogs had negative reactions to the medication. You can even scatter some on your dogs bed. So tick protection is also a must for us. Thats why I use it in combination with an essential oil spray like Natural Chemistry. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. They were extremely helpful people. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Thank you for this. In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. Would this be your recommendation? Just as another concern, I had two cats die from Advantage Multi. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. She is just 1 year old. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. Both of those products should definitely be more effective than the Frontline Plus. Flea Treatment and Prevention In a wellcontrolled laboratory study, SIMPARICA TRIO began to kill fleas at Two years ago he tested positive for lyme disease and was treated with antibiotics. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. The oral chew contains a specially optimised trio of ingredients for . THREE OF THE 8 FEMALES WENT INTO ESTRUS. We gave her the first dose in late February and there were no adverse side effects for Sugar. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. This organic powder is great for a variety of uses. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. Positive feedback keeps me writing! My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Thank you for the warning. PRUEBA GRATUITA FUNCIONES. Second, Id like to ask a question if you dont mind. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Should I give them Trifexis or Sentinel Spectrum? . Thanks. Happy to help! The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Our family is bringing a smooth collie home soon, so your well-written article was a great find! Based on your recommendations, I will not use Vectra. Unfortunately, the fleas are fighting back. Just want to do what is best for them? The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. In summary, use with caution. It covers fleas, ticks, and heart worms. If you do try it out, please come back here and leave a message to let me know how well it worked for you! Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . Tap to zoom. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. My Vet told me Trifexis was safe to give them. Any thoughts? These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Interceptor is the go-to heartworm preventive for many Collie parents. Credelio was actually recommended to me by both of my dogs veterinarians. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. Safety has not been evaluated in pregnant, breeding or lactating dogs. Also, it is not recommended for use with other medications. Eur. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. That averages out to about 212 deaths per year. I do remember her cowering and rubbing her back against her crate after we administered anything topical! Are you also on Instagram, by chance? Seven Collies sound like a lot of work but also very wonderful! However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Fleas start to bite within 5 minutes. . Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. 1 x 5mg tablet for 2.8 to 5.5 pounds. The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. As with everything else, monitor your dog for symptoms. Thanks Emily! Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. enough to have 4 dogs like I do! Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. GestorVet es el futuro de la gestin veterinaria. Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. My pleasure! Grupo de perros 1x, 3x y 5x veces la dosis. . That way if a tick does make it past the essential oil barrier and bite, itll die anyway. Kills 5 types of ticks. Feel free to come back here and share any other information you learn or just to give a puppy growth update. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). The login page will open in a new tab. We do, however, have lots of deer ticks (also known as black legged ticks). Product Description. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. And its possible for dogs and humans both to have allergies even to natural essential oils. I'm planning to go on a camping trip mid-September and my vet prescribed a simparica trio tablet to make sure he's safe from fleas and ticks. If your dogs arent reacting to it, why are you switching? Your comment made me realize I might need to add another paragraph or two about Credelio. Thanks She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . Simparica trio prescribed to 10 wk aussie pup. ? Their treatment for this was nexgard and medicated baths. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Is credelio considered safe when using interceptor? Hi Emily, this is a great article and I appreciate all of your research! Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. I have a female 3 year old collie. The vet thought he would be nice and put Advantage Multi on our cats. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. And each monthly chewable tablet has a palatable liver . I chose Frontline Plus for him as it seems to be an older, safer spot-on. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? That indicates it is a strong chemical compound, so do watch for skin irritation. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Its worth making a phone call to see what they would recommend for your pup. The author states this had no connection to the drug study. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. The Vet is too expensive! In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. In FL resistance is bad, and we split our time between FL & NJ. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. I went back to using Frontline Plus for them. ? 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