The generic is considered to be as safe and effective as the original drug. Drugs in this class prevent your small intestine from absorbing cholesterol. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. Zetia is also available in a generic form called ezetimibe. Some people with POTS also may have one or more . This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. The children took Zetia and simvastatin or simvastatin alone. This is because large meals can cause blood to pool excessively in the abdomen. However, animal studies dont always predict what will happen in humans. Zetia is available in a generic form called ezetimibe. To reduce your symptoms in . Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. 1. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. For instance, some interactions can interfere with how well a drug works. MNT is the registered trade mark of Healthline Media. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. (A class of drugs is a group of medications that work in a similar way.) Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. POTS affects the body's ability to pump blood from the legs to the rest of the body while standing. Cholesterol is made naturally in your liver. Statins shouldnt be used during pregnancy. Statins are drugs used to lower cholesterol. Zetia is a brand-name prescription drug. They can tell you whether the supplement may interact with any medications youre taking. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . Absorption isnt affected by food. Your doctor will likely start you on the typical dosage approved to treat your condition. sinusitis. This is because every persons body responds differently to medications. However, be sure to take the dosage your doctor prescribes for you. But if they become more severe or dont go away, talk with your doctor or pharmacist. Here are answers to some frequently asked questions about Zetia. Before taking Zetia, talk with your doctor and pharmacist. Since every POTS patient is different, some may primarily experience gastrointestinal symptoms, such as nausea, vomiting or poor feeding, Berger explained. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. It belongs to a class of drugs called cholesterol absorption inhibitors. And Zetia hasnt been shown to affect blood sugar levels in clinical studies of people with diabetes and people without diabetes. Tell them about all prescription, over-the-counter, and other drugs you take. We talked to experts about, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Or should I wait to see if I develop such side effects? Plant sterols are similar to cholesterol. Yes, treatment with Zetia should lower your triglycerides. Statin drugs arent safe to use during pregnancy. During your Zetia treatment, consider keeping notes on any side effects youre having. People with this condition have high levels of LDL (bad) cholesterol, high levels of triglycerides, and low levels of HDL (good) cholesterol. Avoid eating foods high in fat or cholesterol, or Zetia will not be as effective. Learn about the drugs dosages, forms, strengths, and more. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. They often originate at the base of the skull and spreading on the back of the head and neck. The symptoms develop immediately and include dizziness and an intense headache. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. If your doctor confirms you had a serious allergic reaction to Zetia, they may have you switch to a different treatment. joint or muscle pain*. These tests will look at your cholesterol levels and also your liver enzyme levels. Fenofibrate belongs to the fibrate drug class. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. They are caused by deficiencies in enzymes involved in the synthesis of heme. 2005-2023 Healthline Media a Red Ventures Company. A malfunctioning ANS is sometimes called 'dysautonomia'. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. Learn about the side effects it can cause and how to manage them. There arent any foods that have been specifically reported to interact with Zetia. Call your doctor right away if you have serious side effects. Is it harmful to take a coenzyme Q10 (CoQ10) supplement along with Zetia to help prevent muscle-related side effects? Brand-name medications usually cost more than generics. A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. For most people, CoQ10 isnt a harmful or dangerous supplement. After first three days stopped it for two days. In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. Side effects could occur in children who are breastfed by someone taking a statin drug. Brain fog. Increased liver enzymes can be a sign of liver damage. If you use Zetia and warfarin together, your doctor may want to monitor you more closely during your treatment. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. The insurance company will review the prior authorization request and decide if the drug will be covered. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. shaking and sweating. The phase IV clinical study analyzes which people take Zetia and have Constipation. Then you can share this information with your doctor. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. There arent any herbs or supplements that have been specifically reported to interact with Zetia. It can also interact with certain supplements as well as certain foods. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. You should store Zetia tablets at a room temperature of 77F (25C) in a tightly sealed container away from light. Note: Some of the drugs listed here are used off-label to treat these specific conditions. If youre pregnant or breastfeeding, or if youre planning to become pregnant or breastfeed, tell your doctor. Zetia can cause certain side effects, some of which are more common than others. diarrhea. Medications in the statin drug class work differently than cholesterol absorption inhibitors like Zetia. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. They may have a preference for one version or the other. (A class of medications is a group of drugs that work in a similar way.) Zetia can cause mild or serious side effects. tender, swollen glands in neck. Zetia may cause joint pain. What causes POTS? Read more about how inherited high cholesterol affects life expectancy and what makes it different from regular hypercholesterolemia. For more information about the effectiveness of Zetia for lowering your triglycerides, see the Zetia uses section above. It's Aimee Esther here! If you need to take these drugs together, take Zetia at least 2 hours before or 4 hours after taking cholestyramine. Crossing your legs in front of each other while standing, rocking up and down on your toes. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). And taking it with Zetia and a statin likely wont cause any problems. The dose of Zetia used for children is the same as the adult dose. At the end of the study, researchers found that: Mixed hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol and fats are cleared from your body. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. If you and your doctor determine that Zetia is safe and effective for you, youll likely take it long term. It belongs to a class of drugs called cholesterol absorption inhibitors. Phase IV trials are used to detect adverse drug . If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. Zetia, Baclofen, and Xanax are not known to cause itching at all, but the Xanax can cause problems with memory which you do describe. Zetia may not be right for you if you have certain medical conditions or other factors affecting your health. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. If your muscle-related side effects dont go away or become severe, tell your doctor right away. Recently, POTS has been diagnosed in some people who have had COVID-19. A large review by the American Heart Association compared studies of CoQ10. Some may be a better fit for you than others. So stopping Zetia may lead to an increase in your cholesterol levels. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. Most of these side effects may go away within a few days or a couple of weeks. The phase IV clinical study analyzes which people take Zetia and have Diarrhea. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. Tramadol will usually cause a blistering type rash with itching which you do not describe. These drugs havent been directly compared in clinical studies. No, stopping Zetia shouldnt cause any side effects. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Females who could become pregnant should use birth control while taking Zetia with a statin drug. Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. * To learn more about this side effect, see the Side effects explained section below. * Zetia is also approved to treat these conditions in children ages 10 years and older. Youll likely take it once a day. You likely wont notice Zetia working in your body. Zetia may cause mild side effects other than the ones listed above. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. An increase in levels of liver enzymes doesnt usually cause any symptoms. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. They may also check you for signs of muscle breakdown or kidney damage. It also isnt known what percentage of adults and children experienced diarrhea in clinical studies of other conditions treated with Zetia. For this purpose, Zetia is used with a low-cholesterol diet and is taken with atorvastatin or simvastatin in adults and in children ages 10 years and older. People who may be at higher risk of this side effect include those who: Tell your doctor if any of the above apply to you before starting Zetia treatment. For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. Zetia does not cause an increase or a decrease in blood pressure. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. Zetia is FDA-approved to treat mixed high cholesterol when used with fenofibrate. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. Healthline Media does not provide medical advice, diagnosis, or treatment. Zetia isnt a statin drug. Can diet help improve depression symptoms? While taking Zetia, tell your doctor right away if you experience extreme muscle pain, muscle tenderness, or dark-colored urine. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Lipitor, or with both drugs (when taken individually). You should always consult your doctor or another healthcare professional before taking any medication. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). They can give you tips on how to deal with any side effects that may be bothersome. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. Then theyll monitor whether the drug is working for you and whether you experience any side effects. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. I am a stay at home mama to a sweet baby girl, and wife to an amazing h. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. Zetia is approved to treat different types of high cholesterol. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about the change in her physical appearance. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. You can take Zetia at any time during the day, but try to take your dose around the same time each day. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. zetia. (A class of drugs is a group of medications that work in a similar way.) Fenofibrate is a drug used to lower your triglyceride levels. Its not known if its safe to take Zetia while breastfeeding or if the drug passes into breast milk. Porphyrias have been associated with POTS symptoms (Stewart & Hensley, 1981). tightness of chest or wheezing. Get answers to some frequently asked questions about Zetias side effects. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. If any of the following factors or conditions apply, you may have a higher risk of developing these muscle problems: If you have muscle-related side effects during Zetia treatment, talk with your doctor. Taking Zetia with a statin drug may increase your risk of developing some mild or serious side effects. Before trying something new, its common to look for written reviews about the experiences of others. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). Instead, it belongs to a class of drugs called cholesterol absorption inhibitors. . Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. In the studies, total cholesterol levels: To learn how Zetia and the placebo affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. You can use the study as a second opinion to make health care decisions. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. Dizziness is a rare side effect of taking Zetia. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. (Mixed hyperlipidemia is also known as mixed high cholesterol.). Nexlizet (bempedoic acid/ezetimibe) is a prescription tablet used to lower LDL (bad) cholesterol in certain people. If you have questions about using Zetia and cholestyramine together, talk with your doctor. Treatment is targeted at relieving low blood volume or regulating circulatory problems that may cause the disorder. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. Muscle-related problems are a possible side effect of Zetia when used with other medications. However, some people have reported experiencing memory loss when taking statin drugs. As with all medications, the cost of Zetia can vary. The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . Lipitor is an HMG-CoA reductase inhibitor (a "statin" drug) and Zetia is a cholesterol -lowering drug. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. Cardiology 33 years experience. But in studies, some people had to stop taking the drug due to feeling dizzy. 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